Smiley face   Molecular Engineering for Cellular Imaging and Reprogramming

2017

  1. Wan Q., TruongVo T., Steele H.E., Ozcelikkale A., Han B., Wang Y., Yokota H., Oh J., Na S. (2017) Subcellular domain-dependent molecular hierarchy of SFK and FAK in mechanotransduction and cytokine signaling (Nature) Scientific Reports, accepted.
  2. Sun J., Lei L. Tsai C.-M., Wang Y., Shi Y., Ouyang M., Lu S., Seong J., Kim T., Wang P., Huang M., Xu X., Nizet V., Chien, S., Wang Y. (2017) Engineered Proteins with Sensing and Activating Modules for Automated Reprogramming of Cellular Functions, Nature Communications, accepted.
  3. Yoon S., Wang P., Peng Q., Wang Y., Shung K.K. (2017) Acoustic-transfection for genomic manipulation of single-cells using high frequency ultrasound, (Nature) Scientific Reports, accepted.
  4. Seong J., Huang M., Sim K., Kim H., Wang Y. (2017) FRET-based Visualization of PDGF Receptor Activation at Membrane Microdomains, (Nature) Scientific Reports, accepted.
  5. Vennin C., Chin V.T., Warren S.C., Lucas M.C., ... Wang Y., ... Pajic M., Timpson P. (2017) Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy and the onset of the metastatic niche, Science Translational Medicine, accepted.

2016

  1. Mao M., Wang L., Chang C.-C., Rothenberg K., Huang J., Wang Y., Hoffman B., Liton P., and Yuan F. (2016) Involvement of a Rac1-dependent macropinocytosis pathway in plasmid DNA delivery by electrotransfection, Molecular Therapy, 25(3): 803-815.
  2. Wang Y. (2016) FRET imaging of molecular hierarchy at subcellular levels in mechanotransduction, Journal of Medical Biomechanics, accepted.
  3. Li K., Xiang X., Sun J., He H.-T., Wu J., Wang Y., and Zhu C. (2016) Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-based Biosensor, The Annals of Biomedical Engineering, 44(12): 3510-3521.
  4. Wu Y., Zhang K., Chien S., Wang Y., and Lu S. (2016) In-situ coupling between kinase activities and protein dynamics within single focal adhesions. (Nature) Scientific Reports, 6: 29377.
  5. Qi Y.X., Yao Q.P., Huang K., Shi Q., Zhang P., Wang G.L., Han Y., Bao H., Wang L., Li H.P., Shen B.H., Wang Y., Chien S., Jiang Z.L. (2016) Nuclear Envelope Proteins Modulate Proliferation of Vascular Smooth Muscle Cells during Cyclic Stretch Application. PNAS, 113(19): 5293-5298.
  6. Peng Q., Cheng B., Lu S., Chien S., and Wang Y. (2016) Perspectives of FRET Imaging to study Epigenetics and Mechanobiology in the Nucleus, Molecular and Cellular Mechanobiology, Springer.
  7. Wang Y. (2016) New Technologies of Molecular Engineering and Screening for Cell Signaling Studies. Molecular Biology of the Cell , 27(6): 875-876.
  8. Le Borgne M., Raju S., Zinselmeyer BH., Le VT., Li J., Wang Y., Miller MJ., Shaw AS. (2016) Real-Time Analysis of Calcium Signals during the Early Phase of T Cell Activation Using a Genetically Encoded Calcium Biosensor. The Journal of Immunology 196(4): 1471-9.
  9. Yoon S., Kim MG., Chiu CT., Hwang JY., Kim HH., Wang Y., and Shung K. (2016) Direct and sustained intracellular delivery of exogenous molecules using acoustic-transfection with high frequency ultrasound, (Nature) Scientific Reports 6: 20477
  10. Wang R, Lei L, Sridharan S, Wang Y, Levine AJ, Popescu G. (2016) Dispersion relations of cytoskeleton dynamics, Cell Health and Cytoskeleton 8: 1-7.

2015

  1. Wang X., Sun J., Xu Q., Chowdhury F., Roein-Peikar M., Wang Y., and Ha T. (2015) Integrin Molecular Tension within Motile Focal Adhesions, Biophysical Journal 109(11): 2259-2267.
  2. Chung E., Ochs C.J., Wang Y., Lei L., Qin Q., Smith A.M., Strongin A.Y., Kamm R., Qi Y.-X., Lu S., Wang Y. (2015) Activatable and Cell-Penetrable Multiplex FRET Nanosensor for Profiling MT1-MMP Activity in Single Cancer Cells, Nano Letters 15(8): 5025-5032.
  3. Zhuo Y., Qian T., Wu Y., Seong J., Gong Y., Ma H., Wang Y., Lu S. (2015) Subcellular and Dynamic Coordination between Src Activity and Cell Protrusion under Microenvironment modulations, (Nature) Scientific Reports 5:12963.
  4. Lee K.L., Guevarra M.D., Nguyen A.M., Chua M.C., Ouyang M., Wang Y., Jacobs J.R. (2015) The primary cilium functions as a mechanical and calcium signaling nexus, Cilia 4:7.
  5. Nishitani1 W.S., Alencar A.M., Wang Y. (2015) Rapid and localized mechanical stimulation and adhesion assay: TRPM7 involvement in calcium signaling and cell adhesion, PLoS ONE 10(5):e0126440.
  6. Han Y., Wang L., Yao Q., Zhang P., Liu B., Wang G.-L., Shen B., Cheng B., Wang Y., Jiang Z., Qi Y. (2015) Nuclear Envelope Proteins Nesprin2 and LaminA Regulate Proliferation and Apoptosis of Vascular Endothelial Cells in Response to Shear Stress, BBA - Molecular Cell Research 1853(5):1165-73.
  7. Kim T.J., Joo C., Seong J., Vafabakhsh R., Botvinick E.L., Berns M.W., Palmer A.E., Wang N., Ha T., Jakobsson E., Sun J., Wang Y. (2015) Distinct mechanisms regulating mechanical force-induced Ca2+ signals at the plasma membrane and the endoplasmic reticulum in human mesenchymal stem cells, eLife 4:e04876.
  8. Sun J., Jakobsson E., Wang Y., Brinker J. (2015) Nanoporous silica-based protocells at multiple scales for designs of life and nanomedicine, Life, 5(1):214-229
  9. Gomez-Godinez V., Shi L.Z., Khatibzadeh N., Rosales D., Preece D., Lei L., Wang Y., Berns M.W. (2015) Laser Induced Shockwave Paired with FRET to Study Intracellular Calcium Release, Microscopy Research and Technique 78(3):195-9.
  10. Chung E.Y., Qin Q., Bhattacharyya A., Lu S., Wang Y. (2015) Nanotechnologies and FRET imaging in live cells, Micro and Nano Techniques in Cell Mechanobiology, Cambridge University Press, In Press
  11. Kim T.J., Zheng S., Sun J., Muhamed I., Wu J., Lei L., Kong X., Leckband D.E., and Wang Y. (2015) Dynamic visualization of a-catenin reveals rapid, reversible conformation switching between tension states, Current Biology, 25(2):218-24

2014

  1. Liu B., Lu S., Hu Y.-L, Liao X., Ouyang M., Wang Y. (2014) RhoA and Membrane Fluidity Mediates the Spatially Polarized Src/FAK Activation in response to Shear Stress, (Nature) Scientific Reports, 4:7008
  2. Hwang K., Wu P., Kim T.J., Lei L., Tian S., Wang Y., Lu Y. (2014) Photocaged DNAzymes as a General Method for Sensing Metal Ions in Living Cells, Angewandte Chemie International Edition 53(50):13798-802
  3. Kim T.J., Sun J., Lu S., Qi Y.X., Wang Y. (2014) Prolonged mechanical stretch initiates intracellular calcium oscillations in human mesenchymal stem cells, PLoS ONE, 9(10):e109378
  4. Sun C., Ouyang M., Alqublan H., Sriranganathan N., Wang Y. and Lu C. (2014) Electroporation-delivered fluorescent protein biosensors for probing molecular activities in cells without genetic encoding, Chem. Comm., 50(78):11536-9
  5. Lu S. and Wang Y. (2014) Single-Cell Imaging of Mechanotransduction in Endothelial Cells. Progress in Molecular Biology and Translational Science. In Press
  6. Aung A., Seo T., Lu S., Wang Y., Jamora C., del Alamo JC, and Varghese S. (2014) 3D Traction stresses activate protease-dependent invasion of cancer cells, Biophysical Journal, 107(11):2528-37
  7. Tan Y., Tajik A., Chen J., Jia Q., Chowdhury F., Wang L, Chen J., Zhang S., Hong Y., Yi H., Wu D., Zhang Y., Wei F., Poh Y.-C., Singh R., Seong J., Lin L.-J., Doganay S., Li Y., Jia H., Ha T., Wang Y., Huang B., Wang N. (2014) Matrix softness regulates plasticity of tumor-repopulating cells via H3K9 demethylation and Sox2 expression, Nature Communications, 5:4619
  8. Hu Y.-L., Lu S., Szeto K.W., Sun J., Wang Y., Lasheras J.C., Chien S. (2014) FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells, (Nature) Scientific Reports, 4:6024
  9. Lu S., Seong J., Chang S.C., Wang Y., Eichorst J.P., Holzer R.G., Ouyang M., Chien S., and Wang Y. (2014) Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells, (Nature) Scientific Reports, 4:5756
  10. Kim TJ, Sun J, Lu S, Zhang J, Wang Y. (2014) The regulation of beta-adrenergic receptor-mediated PKA activation by substrate stiffness through microtubules in human mesenchymal stem cells, Biomaterials, 35(29):8348-56
  11. Hum JM., Day RN., Bidwell JP., Wang Y. Pavalko FM (2014) Mechanical Loading in Osteocytes Induces Formation of a Src/Pyk2/MBD2 Complex That Suppresses Anabolic Gene Expression, PLoS ONE, 9(5):e97942
  12. Lei L., Lu S., Wang Y., Wang Y. (2014) The role of mechanical tension on lipid rafts dependent PDGF-induced TRPC6 activation, Biomaterials, 35(9):2868-77
  13. Ouyang M., Lu S., Wang Y. (2014) Genetically Encoded Fluorescent Biosensors for Live-cell Imaging of MT1-MMP Protease Activity, Methods in Molecular Biology, 1071:163-74

2013

  1. Ntziachristos V., Achilefu S., Wang Y., Lin M. (2013). Special Section on Fluorescence Molecular Imaging Honoring Prof. Roger Tsien, a Pioneer in Biomedical Optics. J Biomed Opt. 18(10):10130
  2. Seong J., Tajik A., Sun J., Guan J.-L., Humphries M.J., Craig S.E., Shekaran A., Garcia A.J., Lu S., Lin M.Z., Wang N., Wang Y. (2013) Distinct biophysical mechanisms of FAK mechanoactivation by different extracellular matrix proteins. Proc Natl Acad Sci USA (Direct Submission), 110(48):19372-7
  3. Liao X., Lu S., Zhuo Y., Wang Y. (2013) The effect of inducible reagent on Src and FAK activity during MSCs differentiation. PLoS ONE, 8(8):e72233
  4. Nobis M, McGhee EJ, Morton JP, Schwarz JP, Karim SA, Quinn J, Edward M, Campbell AD, McGarry LC, Evans TR, Brunton VG, Frame MC, Carragher NO, Wang Y, Sansom OJ, Timpson P, Anderson KI. (2013) Intravital FLIM-FRET imaging reveals dasatinib induced spatial control of Src in pancreatic cancer, Cancer Research, 73(15):4674-86
  5. Sun J., Lu S., Ouyang M., Lin L.J., Zhuo Y., Liu B., Chan R., Chien S., Neel B.G., Wang Y. (2013) Antagonism between binding site affinity and conformational dynamics tunes alternative cis-interactions within Shp2, Nature Communications, 4:2037
  6. Lu S., Huang H., Wang Y., Strongin AY., Wang Y. (2013) Highly Sensitive FRET Biosensors for Detecting MMP Activity in Live Breast Cancer Cells, PLoS ONE, 8(3): e58569
  7. Seong J., Wang N., Wang Y. (2013) Mechanotransduction at Focal Adhesions: from Physiology to Cancer Development, Journal of Cellular and Molecular Medicine, doi: 10.1111/jcmm.12045. [Epub ahead of print]
  8. Ouyang M., Lu S., Chen CN., Kim T., Seong J., Leckband DE., Wang F., Reynolds AB., Schwartz MA., Wang Y. (2013) N-cadherin Differentially Couples with p120ctn and b-catenin to Regulate the Polarity of Distinct Molecular Activities, Nature Communications, 4:1589
  9. Lin L.-J., Grimme J.M., Sun J., Lu S., Gai L., Cropek D.M., Wang Y. (2013) The antagonistic roles of PDGF and integrin αγβ3 in regulating ROS production at focal adhesions, Biomaterials, 34(15):3807-15
  10. Qian T., Lu S., Ma H., Fang J., Zhong W., Wang Y. (2013) FRET Imaging of Microenvironment Effects on Calcium Signaling in Live Cells, Integrative Biology, 5(2):431-8

2012

  1. Brown G, Butler PJ, Chang DW, Chien S, Clegg RM, Dewey CF, Dong C, Guo XE, Helmke BP, Hess H, Jacobs CR, Kaunas RR, Kumar S, Lu HH, Mathur AB, Mow VC, Schmid-Schönbein GW, Skoracki R, Wang N, Wang Y, Zhu C. (2012) Cellular and Molecular Bioengineering: A Tipping Point, Cellular and Molecular Bioengineering, 5(3):239-253
  2. Wang R., Lei L., Wang Y., Levine A.J., and Popescu G. (2012) Dispersion-relation fluorescence spectroscopy, Physics Review Letter, 109(18):188104
  3. *Liao X., *Lu S., Zhuo Y., Wang Y. (2012) Visualization of Src and FAK activity during the differentiation process from HMSCs to osteoblast by FRET biosensor, PLoS ONE, 7(8):e42709
  4. Eichorst JP., Clegg RM., Wang Y. (2012), Red-Shifted Fluorescent Proteins Monitor Enzymatic Activity in Live HT-1080 Cells with Fluorescence Lifetime Imaging Microscopy (FLIM), Journal of Microscopy, 248(1):77-89
  5. Birukova A.A., Tian Y., Dubrovskyi O., Zebda N., Sarich N., Tian X., Wang Y., Birukov K.G. (2012) VE-cadherin Trans-interactions Modulate Rac Activation and Enhancement of Lung Endothelial Barrier by Iloprost, Journal of Cellular Physiology, 227(10):3405-16

2011

  1. *Xiang X., *Sun J., Wu J., He H.T., Wang Y., Zhu C. (2011) A FRET-based biosensor for imaging SYK activities in living cells, Cellular and Molecular Bioengineering, 4(4):670-677
  2. Nishitani WS., Saif TA, Wang Y. (2011) Calcium signaling in live cells on elastic gels under mechanical vibration at subcellular levels, PLoS ONE, 6(10):e26181
  3. *Liao X., *Lu S., Zhuo Y., Winter C., Xu W., Li B., Wang Y. (2011) Bone physiology, biomaterial and the Effect of mechanical/physical microenvironment onmesenchymal stem cell osteogenesis, Cellular and Molecular Bioengineering, 6(6):579-590
  4. Seong J., Ouyang M., Kim T., Sun J., Wen P.-C., Lu S., Zhuo Y., Llewellyn N.M., Schlaepfer D.D., Guan J.L., Chien S., Wang Y. (2011) Detection of focal adhesion kinase activation at Membrane Microdomains by fluorescence resonance energy transfer, Nature Communications, 2:406
  5. Lu S., Kim T., Chen CN., Ouyang M., Seong J., Wang Y. (2011) Computational Analysis of the Spatiotemporal Coordination of Molecular Activities in Live Cells, PLoS ONE, 6(6):e21293
  6. Eichorst JP., Huang H., Clegg RM., Wang Y. (2011) Phase differential enhancement to distinguish fluorescence components when monitoring molecular activity in live cells by FLIM, Journal of Fluorescence, 21(4):1763-77
  7. Liu B., Lu S., Zheng S., Jiang Z.-L., Wang Y. (2011) Two Distinct Phases of Calcium Signaling under Flow, Cardiovascular Research, 91(1):124-33
  8. Seong J., Lu S., Wang, Y. (2011) Live Cell Imaging of Molecular Signaling by FRET, Cellular and Molecular Bioengineering, 4(2):138-147
  9. Butler P.J., Wang, Y. (2011) Editorial Note: Molecular Imaging and Mechanobiology, Cellular and Molecular Bioengineering, 4(2):123-124
  10. Asada HH., Wang Y., Mayalu MN. (2011) Molecular Signaling Observer and Predictor: A Framework for Closed-Loop Control of Cell Behaviors Having Long Time Delay, American Control Conference. 1240:2314-2319

2010

  1. Lu, S., Wang, Y. (2010) FRET Biosensors for Cancer Detection and Evaluation of Drug Efficacy, Clinical Cancer Research, 16(15):3822-4
  2. Gawlik K., Remacle AG., Shiryaev SA., Golubkov VS., Ouyang M., Wang Y., and Strongin AY. (2010) A femtomol range FRET biosensor reports exceedingly low levels of cell surface furin: implications for the processing of anthrax protective antigen, PLoS ONE, 5(6):e11305
  3. Qian T., Wang Y. (2010) Micro/nano-fabrication Technologies for Cell Biology. Medical & Biological Engineering & Computing, 48(10):1023-32
  4. Liu B., Kim T., Wang Y. (2010) Live Cell Imaging of Mechanotransduction. Journal of the Royal Society Interface, 7 Suppl 3:S365-75
  5. Ouyang M.*, Huang H.*, Shaner N., Remacle AG., Shiryaev SA., Strongin AY., Tsien RY., Wang Y. (2010) Simultaneous Visualization of Pro-tumorigenic Src and MT1-MMP Activities with Fluorescence Resonance Energy Transfer. Cancer Research, 70(6):2204-12

2009

  1. Poh Y.C., Na S., Chowdhury F., Ouyang M., Wang Y., Wang N. (2009) Rapid Activation of Rac GTPase in Living Cells by Force Is Independent of Src. PLoS ONE,4(11):e7886
  2. Wang Y., Wang N. (2009) FRET and Mechanobiology. Integrative Biology, 1(10):565-73
  3. Wang Y.*, Flores L.*, Lu S., Miao H., Li Y.-S., Chien S. (2009) Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-kB Pathway via Actin and Tyrosine Kinases. Cellular and Molecular Bioengineering, 2(3):341-350
  4. Kim T., Wang Y. (2009) Single cell imaging of calcium dynamics in response to mechanical stimulation. Cell Mechanics: From Single Scale-Based Models to Multiscale Modeling, 10:265-279
  5. Lu S., Wang Y. (2009) Application of FRET Biosensors and Computational Analysis for Live Cell Imaging. Proc. of SPIE. 7191 (719108):1-12
  6. Kim T., Xu J., Dong R., Lu S., Nuzzo R., Wang Y. (2009) Visualizing the Effect of Microenvironment on the Spatiotemporal RhoA and Src Activities in Live Cells by FRET. Small, 5(12):1453-9.
  7. Na S., Chowdhury F., Tay B., Ouyang M., Gregor M., Wang Y., Wiche G., Wang N. (2009) Plectin contributes to mechanical properties of living cells. Am J PhysiolCell Physiol, 296(4):C868-77
  8. Seong J., Lu, S., Ouyang M., Huang H., Zhang J., Frame MC., Wang Y. (2009) Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chemistry & Biology (Cell Press), 16(1):48-57, (Cover Article)
  9. Kim T., Seong J., Ouyang M., Sun, J., Lu, S., Hong J., Wang, N., Wang Y. (2009) Mechanical rigidity regulates Ca2+ oscillation via RhoA signaling pathway in humanmesenchymal stem cells. Journal of Cellular Physiology, 218(2):285-93

2008

  1. *Eichorst J., *Lu S., Xu J., Wang, Y. (2008) Differential RhoA Dynamics in Migratory and Stationary Cells Measured by FRET and Automated Image Analysis. PLoS ONE, 3(12):e4082
  2. Ouyang M., Sun J., Chien S., Wang Y. (2008) Determination of hierarchical relationship of Src and Rac at subcellular locations with FRET biosensors, Proc Natl Acad Sci USA. 105(38):14353-8
  3. Wang, Y., Shyy Y.-J., Chien, S. (2008) Fluorescence Proteins, Live Cell Imaging, and Mechanobiology: Seeing is Believing, Annual Review of Biomedical Engineering, 10:1-38 (The most downloaded article of ARBE in year 2009)
  4. Lu S., Ouyang M., Seong J., Zhang J., Chien, S., Wang Y. (2008) The Spatiotemporal Pattern of Src Activation at Lipid Rafts Revealed by Diffusion-Corrected FRET Imaging. PLoS Computational Biology, 4(7): e1000127, (Featured Research by PLoS Computational Biology)
  5. Na S., Collin O., Chowdery F., Tay B., Ouyang M., Wang Y., Wang N. (2008) Rapid signal transduction in living cells is a unique feature of mechanotransduction. ProcNatl Acad Sci USA. 105 (18):6626-31
  6. Ouyang M., Lu S., Li X.-Y., Xu J., Seong J., Giepmans B., Shyy Y.-J., Weiss SJ, Wang Y. (2008) Directional MT1-MMP Activity in Live Cells Visualized by a FRET Biosensor, Journal of Biological Chemistry. 283 (25):17740-8
  7. Wang Y., Lu S. (2008) The Application of FRET Biosensors to Visualize Src Activation. Proc. of SPIE. 6868 (68680A):1-9
  8. Wang Y., Shyy, J.-Y., and Chien, S., (2008) Fluorescence Live-Cell Imaging: Principles and Applications in Mechanobiology. Bioengineering in Cell and Tissue Research, pp. 65-84

2007

  1. Wang Y. and Chien, S., (2007) Analysis of Integrin Signaling by Fluorescence Resonance Energy Transfer. Methods in Enzymology, 426:177-201
  2. Botvinick, EL and Wang Y., (2007) Laser Tweezers in the Study of Mechanobiology in Live Cells. Methods in Cell Biology, 82:497-523
  3. Wang Y., Chang JM., Chen K.-D., Li S., Li J., Wu C., Chien S. (2007) Selective Adapter Recruitment and Differential Signaling Networks by VEGF vs. Shear Stress.Proc Natl Acad Sci USA. 104 (21): 8875-9
  4. Larina IV., Wang Y., Chien S., Lane ME., and Dickinson ME. (2007) On the way to subcellular imaging of mechanotransduction in the developing vasculature. Proc. of SPIE. 6535 (653504):1-6

2006

  1. Hu YL., Haga JH., Miao H., Wang Y., Li YS., Chien S. (2006) Roles of microfilaments and microtubules in paxillin dynamics. Biochem Biophys Res Commun. 348(4):1463-71.
  2. Wang Y., Jin G., Miao H., Li J., Usami S., Chien S. (2006) Integrins Regulate VE-cadherin and Catenins: Dependence of This Regulation on Src, but not on Ras. Proc Natl Acad Sci USA. 103(6):1774-79.

1998-2005

  1. Wang Y., Botvinick E., Zhao Y., Berns M., Usami S., Tsien R.Y., Chien S. (2005) Visualization of Mechanical Activation of Src. Nature. 434:1040.
  2. Miao H., Hu Y., Shiu Y.-T., Yuan S., Zhao Y., Kaunas R., Wang Y., Jin G., Usami S., and Chien S. (2005) Effects of Flow Patterns on the Localization and Expression of VE-Cadherin at Vascular Endothelial Cell Junctions: In-vivo and In-vitro Investigations. Journal of Vascular Research. 42:77.
  3. Wang Y., Chang JM., Li Y.-C., Li Y.-S., Shyy J. Y.-J., and Chien S. (2004) Shear Stress and VEGF Activate IKK via Flk-1/Cbl/Akt Signaling Pathway. Am J PhysiolHeart Circ Physiol. 286(2):H685-92.
  4. Shiu Y.-T., Li S., Yuan S., Wang Y., Nguyen P., Chien S. (2003) Shear stress-induced c-fos activation is mediated by Rho in a calcium-dependent manner. BiochemBiophys Res Commun. 303(2):548-55
  5. Wang Y., Miao H., Li S., Chen K.-D., Li Y.-S., Yuan S., Shyy J. Y.-J., and Chien S., (2002) Interplay between integrins and FLK-1 in shear stress- induced signaling. Am J Physiol Cell Physiol. 283: C1540-1548
  6. Miao H., Yuan S., Wang Y., Tsygankov A., Chien S. (2002) Role of Cbl in Shear-Activation of PI 3-kinase and JNK in Endothelial Cells. Biochem Biophys ResCommun. 292(4):892-9
  7. Li S., Butler P., Wang Y., Hu Y., Han D., Usami S., Guan J.-L., Chien S. (2002). The role of the dynamic of focal adhesion kinase in the mechanotaxis of endothelial cells.Proc Natl Acad Sci USA. 99(6):3546-51
  8. Wu W., Wang Y., Yan Z., Wen G. (1999). The Dynamic Coupling Model for the Whole Circulation in Human Body. Acta S cientiarum Naturalium, Universitatis Pekinensis. 35(3): 328-339
  9. Wu W., Wen G., Yan Z., Wang Y., Zhang, Z. (1999). The Dynamic Coupling of Right Ventricle and Pulmonary Arteries. Acta Scientiarum Naturalium, Universitatis Pekinensis. 35(3): 317-327
  10. Wang Y., Wu W., Wen G. (1999). The Influence of Aortic Valve on the Cardiovascular Coupling. Journal of Hydrodynamics. 14(1): 13-23.
  11. Wang Y., Wu W., Wen G. (1998). The Influence of Cardiovascular Dynamic Coupling on the Blood Pulse Wave Propagation in Human Body. Applied Mathematics and Mechanics. 19(7):601-614

Copyright: Peter Wang Lab. WebMaster - kalu@ucsd.edu, qqin@eng.ucsd.edu